Alpha-methylserotonin, a substitute transmitter for serotonergic neurons

@article{Sourkes1990AlphamethylserotoninAS,
  title={Alpha-methylserotonin, a substitute transmitter for serotonergic neurons},
  author={Theodore L. Sourkes and Thomas Jude Montine and Krystyna Missala},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1990},
  volume={14},
  pages={829-832}
}
Alpha-methyltryptophan as a therapeutic agent
  • T. Sourkes
  • Biology, Psychology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1991
α-Methyl-l-tryptophan as a weight-loss agent in multiple models of obesity in mice
TLDR
It is concluded that α-MLT is an effective, reversible, and orally active drug for the treatment of obesity and metabolic syndrome.
Alpha [11C] Methyl-l-tryptophan positron emission tomography in epilepsy
TLDR
This study presents a novel probabilistic procedure, called a ‘spiking-spiking lesion’, which is able to be fitted with a central nervous system excision machine (CGM) and shows promise in predicting Parkinson's disease.
Positron emission tomography (PET) scan in epilepsy
TLDR
Positron Emission Tomography has potential in determining eloquent brain areas and in studying mechanisms of epilepsy, and can be used with worthwhile cost-benefit even in a country with limited resources in epilepsy surgery.

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An autoradiographic method is described to measure the in vivo rate of serotonin synthesis in rat brain, based on the use of the l-tryptophan analogue a-methyl-l-tiptophan (a-MTrp), which is converted in vivo into a-M5HT.
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  • Biology, Chemistry
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A significant role is demonstrated for transmembrane cationic gradients in the control of synaptosomal respiration and mitochondrial oxidative phosphorylation in the adult rat by a rapid technique involving the use of centrifugation in a Ficoll‐sucrose discontinuous gradient.
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TLDR
Results suggest that the decrease in rat brain 5‐HT and 5‐HIAA following hydrocortisone may be associated with the rise in liver tryptophan pyrrolase and that the brain amine changes are mediated through the decreases in brain tryptophile concentration.
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