Alpha-methylserotonin, a substitute transmitter for serotonergic neurons

@article{Sourkes1990AlphamethylserotoninAS,
  title={Alpha-methylserotonin, a substitute transmitter for serotonergic neurons},
  author={Theodore L. Sourkes and Thomas Jude Montine and Krystyna Missala},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={1990},
  volume={14},
  pages={829-832}
}
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Alpha-methyltryptophan as a therapeutic agent
  • T. Sourkes
  • Biology, Psychology
    Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 1991
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Positron Emission Tomography has potential in determining eloquent brain areas and in studying mechanisms of epilepsy, and can be used with worthwhile cost-benefit even in a country with limited resources in epilepsy surgery.
Alpha Methyl 5 Hydroxytryptamine

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TLDR
An autoradiographic method is described to measure the in vivo rate of serotonin synthesis in rat brain, based on the use of the l-tryptophan analogue a-methyl-l-tiptophan (a-MTrp), which is converted in vivo into a-M5HT.
Determination of indoles in human and rat pineal.
A New Method to Measure Brain Serotonin Synthesis in vivo. II. A Practical Autoradiographic Method Tested in Normal and Lithium-Treated Rats
TLDR
This is the first investigation to demonstrate, with autoradiographic resolution (∼100 μm), the differential changes in the rate of serotonin synthesis in the brain.
Effects of p-chlorophenylalanine and α-methyltryptophan on behaviour and brain 5-hydroxyindoles
CATION MODULATION OF SYNAPTOSOMAL RESPIRATION
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  • Biology, Chemistry
    Journal of neurochemistry
  • 1972
TLDR
A significant role is demonstrated for transmembrane cationic gradients in the control of synaptosomal respiration and mitochondrial oxidative phosphorylation in the adult rat by a rapid technique involving the use of centrifugation in a Ficoll‐sucrose discontinuous gradient.
LIVER AND BRAIN TRYPTOPHAN METABOLISM FOLLOWING HYDROCORTISONE ADMINISTRATION TO RATS AND GERBILS
TLDR
Results suggest that the decrease in rat brain 5‐HT and 5‐HIAA following hydrocortisone may be associated with the rise in liver tryptophan pyrrolase and that the brain amine changes are mediated through the decreases in brain tryptophile concentration.
Protein measurement with the Folin phenol reagent.
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