Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts.

@article{Dudek2014AlphaLA,
  title={Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts.},
  author={Magdalena B Dudek and Joanna Knutelska and Marek Bednarski and L. Wieslaw Nowinski and Małgorzata Zygmunt and Anna Bilska-Wilkosz and Małgorzata B Iciek and Monika Otto and Iwona Żytka and Jacek Sapa and Lidia B Włodek and Barbara Filipek},
  journal={Pharmacological reports : PR},
  year={2014},
  volume={66 3},
  pages={
          499-504
        }
}
The cardiovascular effects of alpha lipoic acid were evaluated in isolated rat hearts exposed to ischemia-reperfusion injury in vitro. Alpha-lipoic acid raised the level of sulfane sulfur playing an important role in the release of hydrogen sulfide. H2S was shown to prevent the post-reperfusion arrhythmias and to protect the cardiomyocytes from death caused by hypoxia. The activation of potassium ATP-sensitive channels (K(ATP) channels) is one of the most important mechanisms of action of… CONTINUE READING
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References

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SHOWING 1-10 OF 35 REFERENCES

Sulfur signaling: is the agent sulfide or sulfane?

  • Analytical biochemistry
  • 2011
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Cardioprotective effects of hydrogen sulfide

G Szabó, G Vere, +3 authors Miesel-GröschelCh
  • Nitric Oxide
  • 2011
VIEW 2 EXCERPTS

Thioredoxin dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to pro duce hydrogen sulfide

Y Mikura, N Shibuya, +3 authors H. Kimura
  • Biochem J 2011;439:479–85
  • 2011
VIEW 1 EXCERPT