Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation.

@article{He2012AlphaLA,
  title={Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation.},
  author={Lan He and Bin Liu and Zhong Dai and Hong-feng Zhang and Yi-shuai Zhang and Xiu-ju Luo and Qi-lin Ma and Jun Peng},
  journal={European journal of pharmacology},
  year={2012},
  volume={678 1-3},
  pages={32-8}
}
Recent studies demonstrate that alpha lipoic acid can prevent nitroglycerin tolerance by restoring aldehyde dehydrogenase 2 (ALDH2) activity and ALDH2-mediated detoxification of aldehydes is thought as an endogenous mechanism against ischemia-reperfusion injury. This study was performed to explore whether the cardioprotective effect of alpha lipoic acid was related to activation of ALDH2 and the underlying mechanisms. In a Langendorff model of ischemia-reperfusion in rats, cardiac function… CONTINUE READING
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