Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway.

@article{Mller2003AlphalipoicAP,
  title={Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway.},
  author={Christian M{\"u}ller and Friedrich Duenschede and Elke Koch and Angelika M. Vollmar and Alexandra K Kiemer},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2003},
  volume={285 4},
  pages={G769-78}
}
In liver resection and transplantation ischemia-reperfusion injury (IRI) is one of the main causes of organ dys- or nonfunction. The aim of the present study was to determine whether alpha-lipoic acid (LA) is able to attenuate IRI. Rat livers were perfused with Krebs-Henseleit buffer with or without LA (+/-wortmannin), followed by ischemia (1 h, 37 degrees C) and reperfusion (90 min). Efflux of lactate dehydrogenase (LDH) and purine nucleoside phosphorylase (PNP) and hepatic ATP content were… CONTINUE READING

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