Alpha-lipoic acid inhibits TNF-alpha-induced apoptosis in human bone marrow stromal cells.

@article{Byun2005AlphalipoicAI,
  title={Alpha-lipoic acid inhibits TNF-alpha-induced apoptosis in human bone marrow stromal cells.},
  author={Chul Hyun Byun and Jungmin Koh and Dong Kwan Kim and Seung Il Park and Kit-mei Gloria. Lee and Ghi Su Kim},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2005},
  volume={20 7},
  pages={
          1125-35
        }
}
UNLABELLED TNF-alpha is an important mediator of bone loss. In the HS-5 hBMSC, TNF-alpha and H2O2 increased intracellular ROS levels and induced cell apoptosis through activation of caspases, JNK and NF-kappaB. alpha-Lipoic acid prevented these changes induced by TNF-alpha and H2O2, suggesting its potential therapeutic applications in attenuating bone loss. INTRODUCTION Oxidative stress is an important mediator of bone loss. TNF-alpha, which plays a critical role in the bone loss after… CONTINUE READING

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