Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways.

@article{Park2008AlphalipoicAD,
  title={Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways.},
  author={Keun Gyu Park and Ae-Kyung Min and Eun Hee Koh and Hyoun Sik Kim and Mi-Ok Kim and H N Park and Yong-Deuk Kim and Tae-seung Yoon and B. K. Jang and Jae Seok Hwang and Jae Bum Kim and Hueng-Sik Choi and Joong-Yeol Park and In-kyu Lee and K Lee},
  journal={Hepatology},
  year={2008},
  volume={48 5},
  pages={1477-86}
}
UNLABELLED Fatty liver is common in obese subjects with insulin resistance. Hepatic expression of sterol regulatory element binding protein-1c (SREBP-1c), which plays a major role in hepatic steatosis, is regulated by multiple factors, including insulin, adenosine monophosphate-activated protein kinase (AMPK), liver X receptors (LXRs), and specificity protein 1. Alpha-lipoic acid (ALA), a naturally occurring antioxidant, has been shown to decrease lipid accumulation in skeletal muscle by… CONTINUE READING