Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed

@article{Nordstrm1995AlphalinolenicAI,
  title={Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed},
  author={Dan C. E. Nordstr{\"o}m and Claes Friman and Yrj{\"o} T. Konttinen and V. E. A. Honkanen and Yoshitsugu Nasu and Eeva Antila},
  journal={Rheumatology International},
  year={1995},
  volume={14},
  pages={231-234}
}
In rheumatoid arthris s various pro-inflammatory metabolites of arachidonic acid (AA), such as leukotriene B4 (LTB4) and prostaglandin E2 (PGE2), contribute to tissue destruction and pain. In contrast to AA, which is an omega-6 fatty acid, the omega-3 fatty acids, after having been liberated from the cell membrane phospholipids, are further converted into the non-or anti-inflammatory eicosanoids LTB5 and PGI3. AA concentration is an important regulatory step in the synthesis of both prostanoids… CONTINUE READING
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