Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate.

@article{Monder1967AlphaketoAD,
  title={Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate.},
  author={Carl Monder},
  journal={The Journal of biological chemistry},
  year={1967},
  volume={242 20},
  pages={4603-9}
}
  • Carl Monder
  • Published 1967 in The Journal of biological chemistry
An enzyme which catalyzes the oxidation of methylglyoxal to pyruvic acid was partially purified from aqueous extracts of sheep liver acetone powders. NAD+ or NADP+ was necessary for the oxidation. Changes in methylglyoxal, pyruvate, and pyridine nucleotide were stoichiometrically equivalent. Of various carbonyl-containing compounds tested, only oc-keto aldehydes were substrates. Enzyme activity was found only in the supernatant fraction of liver cells. Evidence is presented that the conversion… CONTINUE READING