Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells.

@article{Chen2006AlphaIP,
  title={Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells.},
  author={Keyang Chen and Jialing Huang and Chune Zhang and Sophia Huang and Giuseppe Nunnari and Feng-xiang Wang and Xiangrong Tong and Ling Gao and Kristi Nikisher and Hui Bin Zhang},
  journal={Journal of virology},
  year={2006},
  volume={80 15},
  pages={
          7645-57
        }
}
The interferon (IFN) system, including various IFNs and IFN-inducible gene products, is well known for its potent innate immunity against wide-range viruses. Recently, a family of cytidine deaminases, functioning as another innate immunity against retroviral infection, has been identified. However, its regulation remains largely unknown. In this report, we demonstrate that through a regular IFN-alpha/beta signal transduction pathway, IFN-alpha can significantly enhance the expression of… CONTINUE READING

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