Alpha-interferon induces depletion of intracellular iron content and upregulation of functional transferrin receptors on human epidermoid cancer KB cells.

@article{Caraglia1994AlphainterferonID,
  title={Alpha-interferon induces depletion of intracellular iron content and upregulation of functional transferrin receptors on human epidermoid cancer KB cells.},
  author={Michele Caraglia and Anna Libroia and S Corradino and Vincenzo Coppola and Rosario Guarrasi and Carmen Barile and Geppino Genua and Angelo Raffaele Bianco and Piersandro Tagliaferri},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={203 1},
  pages={281-8}
}
We have demonstrated that interferon-alpha (IFN alpha) upregulates the epidermal growth factor receptor (EGF-R) on human epidermoid carcinoma cells. Here we report that IFN alpha induces growth inhibition and upregulation of transferrin receptor (TRF-R) on epidermoid cancer KB cells. IFN alpha does not alter TRF-R affinity for its ligand and induces a two… CONTINUE READING