Alpha-interferon in combination with 5-fluorouracil and leucovorin in metastatic colorectal cancer: a phase I study

A high rate of response to 5-fluorouracil (5FU) and alpha-interferon (αIFN) combination therapy has been reported in metastatic colorectal cancer patients. There-fore, designed a trial of high-dose continuous-infusion 5FU, oral leucovorin (LV), and αIFN in this group of patients. Because this combination has not previously been tested and severe toxicity… CONTINUE READING