Alpha interferon as an adenovirus-vectored vaccine adjuvant and antiviral in Venezuelan equine encephalitis virus infection.

@article{OBrien2009AlphaIA,
  title={Alpha interferon as an adenovirus-vectored vaccine adjuvant and antiviral in Venezuelan equine encephalitis virus infection.},
  author={Lyn M O'Brien and Stuart D. Perkins and Amanda J. Williams and Lin S. Eastaugh and Amanda Phelps and Josh Chia-Ching Wu and Robert J Phillpotts},
  journal={The Journal of general virology},
  year={2009},
  volume={90 Pt 4},
  pages={874-82}
}
There are no widely available vaccines or antiviral drugs capable of protecting against infection with Venezuelan equine encephalitis virus (VEEV), although an adenovirus vector expressing VEEV structural proteins protects mice from challenge with VEEV and is potentially a vaccine suitable for human use. This work examines whether alpha interferon (IFN-alpha) could act as an adjuvant for the adenovirus-based vaccine. IFN-alpha was either expressed by a plasmid linked to the adenovirus vaccine… CONTINUE READING

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