Alpha-human atrial natriuretic peptide, carperitide, reduces infarct size but not arrhythmias after coronary occlusion/reperfusion in dogs.

@article{Takagi2000AlphahumanAN,
  title={Alpha-human atrial natriuretic peptide, carperitide, reduces infarct size but not arrhythmias after coronary occlusion/reperfusion in dogs.},
  author={Gen Takagi and Kaname Kiuchi and Takao Endo and Tadashi Yamamoto and Nagaaki Sato and Jun Nejima and Teruo Takano},
  journal={Journal of cardiovascular pharmacology},
  year={2000},
  volume={36 1},
  pages={22-30}
}
Carperitide, a recombinant form of alpha-hANP, possesses potent diuretic, natriuretic, and vasodilatory activity, and inhibits the renin-aldosterone system and sympathetic nervous activity. However, its beneficial effects on ischemic myocardium have not been studied fully. We examined carperitide's effects on infarct size, hemodynamics, and arrhythmia frequency in anesthetized dogs (n = 20) subjected to a 90-min coronary artery occlusion/6-h reperfusion protocol. Intravenous infusion of… CONTINUE READING
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