Alpha-glutathione s-transferase (alpha-GST) release, an early indicator of carbon tetrachloride hepatotoxicity in the rat.

@article{Clarke1997AlphaglutathioneS,
  title={Alpha-glutathione s-transferase (alpha-GST) release, an early indicator of carbon tetrachloride hepatotoxicity in the rat.},
  author={Hugh Clarke and David Egan and M. Heffernan and Sandra L Doyle and C M Byrne and Cormac G. Kilty and Michael P. Ryan},
  journal={Human & experimental toxicology},
  year={1997},
  volume={16 3},
  pages={154-7}
}
1. The use of the cytoplasmic enzyme, alpha glutathione s-transferase (alpha-GST) as an early index of carbon tetrachloride (CCl4) toxicity in the rat was investigated and compared with a standard enzyme, marker, aspartate aminotransferase (AST). The hepatotoxic effects of CCl4 in the rat were determined in a time and dose-response study. 2. Following CCl4 exposure, alpha-GST release was shown to be an earlier and more sensitive biomarker of hepatotoxicity than AST. 3. Significant increases in… CONTINUE READING

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