Alpha-galactosylceramide promotes killing of Listeria monocytogenes within the macrophage phagosome through invariant NKT-cell activation.

@article{Emoto2010AlphagalactosylceramidePK,
  title={Alpha-galactosylceramide promotes killing of Listeria monocytogenes within the macrophage phagosome through invariant NKT-cell activation.},
  author={Masashi Emoto and Tomomi Yoshida and Toshio Fukuda and Ikuo Kawamura and Masao Mitsuyama and Eiji Kita and Robert Hurwitz and Stefan H. E. Kaufmann and Yoshiko Emoto},
  journal={Infection and immunity},
  year={2010},
  volume={78 6},
  pages={
          2667-76
        }
}
alpha-Galactosylceramide (alpha-GalCer) has been exploited for the treatment of microbial infections. Although amelioration of infection by alpha-GalCer involves invariant natural killer T (iNKT)-cell activation, it remains to be determined whether macrophages (Mphi) participate in the control of microbial pathogens. In the present study, we examined the participation of Mphi in immune intervention in infection by alpha-GalCer using a murine model of listeriosis. Phagocytic and bactericidal… CONTINUE READING
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