Corpus ID: 45130023

Alpha-galactosylceramide-induced liver injury in mice is mediated by TNF-alpha but independent of Kupffer cells.

@article{Biburger2005AlphagalactosylceramideinducedLI,
  title={Alpha-galactosylceramide-induced liver injury in mice is mediated by TNF-alpha but independent of Kupffer cells.},
  author={M. Biburger and G. Tiegs},
  journal={Journal of immunology},
  year={2005},
  volume={175 3},
  pages={
          1540-50
        }
}
NKT cells expressing phenotypic markers of both T and NK cells seem to be pivotal in murine models of immune-mediated liver injury, e.g., in Con A-induced hepatitis. Also alpha-galactosylceramide (alpha-GalCer), a specific ligand for invariant Valpha14 NKT cells, induces hepatic injury. To improve the comprehension of NKT-cell mediated liver injury, we investigated concomitants and prerequisites of alpha-GalCer-induced hepatitis in mice. Liver injury induced by alpha-GalCer injection into C57BL… Expand
Targeting the diverse immunological functions expressed by hepatic NKT cells
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