Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.

@article{Lyssand2010Alphadystrobrevin1RA,
  title={Alpha-dystrobrevin-1 recruits alpha-catulin to the alpha1D-adrenergic receptor/dystrophin-associated protein complex signalosome.},
  author={John S. Lyssand and Jennifer L. Whiting and Kyung-Soon Lee and Ryan Kastl and Jennifer L. Wacker and Michael R Bruchas and Mayumi Miyatake and Lorene K Langeberg and Charles Chavkin and John D Scott and Richard G. Gardner and Marvin E. Adams and Chris Hague},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 50},
  pages={21854-9}
}
α(1D)-Adrenergic receptors (ARs) are key regulators of cardiovascular system function that increase blood pressure and promote vascular remodeling. Unfortunately, little information exists about the signaling pathways used by this important G protein-coupled receptor (GPCR). We recently discovered that α(1D)-ARs form a "signalosome" with multiple members of the dystrophin-associated protein complex (DAPC) to become functionally expressed at the plasma membrane and bind ligands. However, the… CONTINUE READING

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