Alpha-cyclodextrin/oil beads as a new carrier for improving the oral bioavailability of lipophilic drugs.

@article{Trichard2007AlphacyclodextrinoilBA,
  title={Alpha-cyclodextrin/oil beads as a new carrier for improving the oral bioavailability of lipophilic drugs.},
  author={Laury Trichard and Elias Fattal and Madeleine Besnard and Am{\'e}lie Bochot},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2007},
  volume={122 1},
  pages={
          47-53
        }
}
The purpose of the present work was to investigate the potential of novel lipid-carrier "beads" consisting of minispheres made of alpha-cyclodextrin and soybean oil for the encapsulation and the oral delivery of drugs. Isotretinoin was chosen as a model of poorly-stable and lipophilic molecule. Isotretinoin-loaded beads were prepared, characterised and administrated orally in rats. Isotretinoin previously dissolved in soybean oil had no significant effect upon bead preparation and… CONTINUE READING
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