Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains.

@article{Gromada2007AlphacellsOT,
  title={Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remains.},
  author={Jesper Gromada and Isobel Franklin and Claes B Wollheim},
  journal={Endocrine reviews},
  year={2007},
  volume={28 1},
  pages={84-116}
}
Glucagon, a hormone secreted from the alpha-cells of the endocrine pancreas, is critical for blood glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia to induce hepatic glucose output. The control of glucagon secretion is multifactorial and involves direct effects of nutrients on alpha-cell stimulus-secretion coupling as well as paracrine regulation by insulin and zinc and other factors secreted from neighboring beta- and delta-cells within the islet… CONTINUE READING
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