Alpha cells, the main source of IL-1β in human pancreas.

@article{Anquetil2017AlphaCT,
  title={Alpha cells, the main source of IL-1β in human pancreas.},
  author={F. Anquetil and Somayeh Sabouri and C. Thivolet and T. Rodriguez-Calvo and J. Zapardiel-Gonzalo and N. Amirian and D. Schneider and E. Castillo and Yasaman Lajevardi and M. V. von Herrath},
  journal={Journal of autoimmunity},
  year={2017},
  volume={81},
  pages={
          68-73
        }
}
Interleukin-1β (IL-1β) is known to trigger beta cell dysfunction in vitro and could potentially play a role during the pathogenesis of type 1 diabetes and type 2 diabetes. However, several clinical trials attempting to block IL-1β function have had minimal success. We therefore re-investigated local expression of IL-1β in human diabetic and non-diabetic pancreata. We obtained pancreatic tissue sections from the Network for Pancreatic Organ Donors with Diabetes (nPOD) including non-diabetic (n… Expand
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