Alpha cell dysfunction in type 1 diabetes

  title={Alpha cell dysfunction in type 1 diabetes},
  author={G. Yosten},
  • G. Yosten
  • Published 2018
  • Medicine
  • Peptides
  • HighlightsDysregulation of the alpha cell and glucagon release is a hallmark of type 1 diabetes.Impaired regulation of pancreatic peptides, such as somatostatin and neuronostatin, can contribute to alpha cell dysregulation.Alpha cell dysfunction is a progressive phenomenon that is associated with progressive loss of glucagon regulation. ABSTRACT Type 1 diabetes is characterized by selective loss of beta cells and insulin secretion, which significantly impact glucose homeostasis. However, this… CONTINUE READING
    11 Citations

    Paper Mentions

    Interventional Clinical Trial
    Glucagon regulation and response in persons with T1D at the basal state and in response to various stimuli remains unclear. Dr. Philip Cryer has previously reported that, in T1D young… Expand
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