Alpha cell dysfunction in type 1 diabetes

@article{Yosten2018AlphaCD,
  title={Alpha cell dysfunction in type 1 diabetes},
  author={G. Yosten},
  journal={Peptides},
  year={2018},
  volume={100},
  pages={54-60}
}
HighlightsDysregulation of the alpha cell and glucagon release is a hallmark of type 1 diabetes.Impaired regulation of pancreatic peptides, such as somatostatin and neuronostatin, can contribute to alpha cell dysregulation.Alpha cell dysfunction is a progressive phenomenon that is associated with progressive loss of glucagon regulation. ABSTRACT Type 1 diabetes is characterized by selective loss of beta cells and insulin secretion, which significantly impact glucose homeostasis. However, this… Expand
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References

SHOWING 1-10 OF 78 REFERENCES
Glucagon and Type 2 Diabetes: the Return of the Alpha Cell
TLDR
This review focuses on the regulation of glucagon secretion by the incretin hormones glucagon-like peptide-1 (GLP-1) and GIP and potential advantages and limitations of suppressing glucagon glands or antagonizing the glucagon receptor in the treatment of patients with type 2 diabetes. Expand
Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes.
TLDR
A focus in this review has been the multiple control levels that modulate glucagon secretion from glucose and nutrients to paracrine and neural inputs and the glucagon actions on glycaemia and energy metabolism. Expand
Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover.
TLDR
It is concluded that glucose-responsive β cells normally regulate juxtaposed α cells and that without intraislet insulin, unregulated α cells hypersecrete glucagon, which directly causes the symptoms of diabetes, indicating that glucagon suppression or inactivation may provide therapeutic advantages over insulin monotherapy. Expand
β-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans.
TLDR
The data suggest that poor β-cell glucose sensitivity is linked to islet transdifferentiation, possibly from α cells to β cells, in an attempt to cope with higher demands for insulin secretion. Expand
Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes
TLDR
It is shown that α cell KATP-channel activity is very low under hypoglycemic conditions and that hyperglycemia, via elevated intracellular ATP/ADP, leads to complete inhibition, suggesting that impaired metabolic control of the KATp channels underlies the defective glucose regulation of glucagon secretion in type 2 diabetes. Expand
Regulation of calcium in pancreatic α- and β-cells in health and disease
TLDR
The mechanisms that underlie the reciprocal regulation of insulin and glucagon secretion by changes in plasma glucose are discussed, the roles played by different types of voltage-gated Ca2+-channel present in α- and β-cells and the modulation of hormone secretion by Ca2-dependent and -independent processes are considered. Expand
Glucose regulation of glucagon secretion independent of B cell activity.
TLDR
In vivo, in man, glucose has an effect on the pancreatic A cell which is independent of intraislet B cell influences. Expand
The Glucagonostatic and Insulinotropic Effects of Glucagon-Like Peptide 1 Contribute Equally to Its Glucose-Lowering Action
TLDR
It is concluded that insulin stimulation (day 4) and glucagon inhibition (day 3) contribute equally to the effect of GLP-1 on glucose turnover in patients with type 2 diabetes, and these changes explain the glucose-lowering effect ofglucagon-1 (day 5 vs. day 1). Expand
Role of Endogenous GLP-1 and GIP in Beta Cell Compensatory Responses to Insulin Resistance and Cellular Stress
TLDR
Observations cannot be explained by simple changes in circulating incretin concentrations, suggesting that intra-islet GLP-1 and GIP make a significant contribution to islet adaptation, particularly expansion of beta cell mass and compensatory islet compensation to hydrocortisone and insulin resistance. Expand
Glucose regulation of glucagon secretion.
TLDR
It is argued that different regulatory processes are involved in a glucose concentration-dependent manner for the glucagon response to hypoglycaemia and the paradoxical hyperglucagonemia in persons with diabetes. Expand
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4
5
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