Alpha-catulin, a Rho signalling component, can regulate NF-kappaB through binding to IKK-beta, and confers resistance to apoptosis.

@article{Wiesner2008AlphacatulinAR,
  title={Alpha-catulin, a Rho signalling component, can regulate NF-kappaB through binding to IKK-beta, and confers resistance to apoptosis.},
  author={Christoph Wiesner and Gabriele Winsauer and Ulrike Resch and Martina Hoeth and Johannes A. Schmid and Jolanda van Hengel and Frans van Roy and Bernd R. Binder and Rainer de Martin},
  journal={Oncogene},
  year={2008},
  volume={27 15},
  pages={2159-69}
}
Rho GTPases regulate diverse cellular functions including adhesion, cytokinesis and motility, as well as the activity of the transcription factors NF-kappaB, serum response factor and C/EBP. alpha-Catulin, an alpha-catenin-related protein that shares structural similarities with cytoskeletal linker proteins, facilitates Rho signalling by serving as a scaffold for the Rho-specific guanine nucleotide exchange factor Lbc. We report here that alpha-catulin also interacts with a key component of the… CONTINUE READING
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