Alpha-bromo-alpha,alpha-difluoroallyl derivatives as synthetic intermediate: nucleophilic substitution of alpha-bromo-alpha,alpha-difluoroallyl derivatives in the presence of palladium catalysts.

@article{Kirihara2000Alphabromoalphaalphadifluoroallyl,
  title={Alpha-bromo-alpha,alpha-difluoroallyl derivatives as synthetic intermediate: nucleophilic substitution of alpha-bromo-alpha,alpha-difluoroallyl derivatives in the presence of palladium catalysts.},
  author={Masaharu Kirihara and Tomofumi Takuwa and Maiko Okumura and Takahiro Wakikawa and Hideo Takahata and Toshiaki Haruka Momose and Yasuo Takeuchi and H Nakagawa Nemoto},
  journal={Chemical & pharmaceutical bulletin},
  year={2000},
  volume={48 6},
  pages={
          885-8
        }
}
The palladium catalyzed nucleophilic substitution of alpha-bromo-alpha,alpha-difluoroallyl derivatives turned out to be an efficient method for the preparation of several fluorinated organic molecules. Several soft carbon nucleophiles regioselectively reacted with 3-bromo-3,3-difluoropropene (BDFP) to give the 3-substituted 1,1-difluoroalkenes. Phenylzinc chloride and tributylphenyltin afforded 1-fluoro-1,3-diphenylpropene. The radical bromination of 3-substituted 1,1-difluoroalkenes provided 1… CONTINUE READING
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