Alpha beta lineage-committed thymocytes can be rescued by the gamma delta T cell receptor (TCR) in the absence of TCR beta chain.

@article{Livk1997AlphaBL,
  title={Alpha beta lineage-committed thymocytes can be rescued by the gamma delta T cell receptor (TCR) in the absence of TCR beta chain.},
  author={Ferenc Liv{\'a}k and Anne M. Wilson and H Robson Macdonald and David G Schatz},
  journal={European journal of immunology},
  year={1997},
  volume={27 11},
  pages={
          2948-58
        }
}
Commitment of the alpha beta and gamma delta T cell lineages within the thymus has been studied in T cell receptor (TCR)-transgenic and TCR mutant murine strains. TCR gamma delta-transgenic or TCR beta knockout mice, both of which are unable to generate TCR alpha beta-positive T cells, develop phenotypically alpha beta-like thymocytes in significant proportions. We provide evidence that in the absence of functional TCR beta protein, the gamma delta TCR can promote the development of alpha beta… CONTINUE READING
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