Alpha beta-crystallin expression and presentation following infection with murine gammaherpesvirus 68.

@article{Chauhan2013AlphaBE,
  title={Alpha beta-crystallin expression and presentation following infection with murine gammaherpesvirus 68.},
  author={Vinita S. Chauhan and Daniel A. Nelson and Ian Marriott and Kenneth L. Bost},
  journal={Autoimmunity},
  year={2013},
  volume={46 6},
  pages={399-408}
}
Alpha beta-crystallin (CRYAB) is a small heat shock protein that can function as a molecular chaperone and has protective effects for cells undergoing a variety of stressors. Surprisingly, CRYAB has been identified as one of the dominant autoantigens in multiple sclerosis. It has been suggested that autoimmune mediated destruction of this small heat shock protein may limit its protective effects, thereby exacerbating inflammation and cellular damage during multiple sclerosis. It is not… CONTINUE READING

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