Alpha- and beta-xylosides alter glycolipid synthesis in human melanoma and Chinese hamster ovary cells.

@article{Freeze1993AlphaAB,
  title={Alpha- and beta-xylosides alter glycolipid synthesis in human melanoma and Chinese hamster ovary cells.},
  author={Hudson H. Freeze and Dilip Sunnyvale Sampath and Ajit Varki},
  journal={The Journal of biological chemistry},
  year={1993},
  volume={268 3},
  pages={
          1618-27
        }
}
beta-D-Xylosides are often used to competitively inhibit proteoglycan synthesis by serving as primers for free glycosaminoglycan (GAG) chain assembly. Quite unexpectedly, we found that when human melanoma cells and Chinese hamster ovary cells are labeled with [3H] galactose in the presence of 4-methyl umbelliferyl beta-D-xyloside (Xyl beta 4MU), a large portion of the labeled acceptor does not consist of the expected GAG chains, but of the novel GM3 ganglioside-like structure: Sia-alpha 2,3-[3H… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

Similar Papers

Loading similar papers…