Alpha- and beta-scorpion toxins evoke glutamate release from rat cortical synaptosomes with different effects on [Na+]i and [Ca2+]i.

@article{Massensini1998AlphaAB,
  title={Alpha- and beta-scorpion toxins evoke glutamate release from rat cortical synaptosomes with different effects on [Na+]i and [Ca2+]i.},
  author={Andr{\'e} Ricardo Massensini and Tasso Moraes-Santos and Marcus Vin{\'i}cius Gomez and Marco Aur{\'e}lio Romano-Silva},
  journal={Neuropharmacology},
  year={1998},
  volume={37 3},
  pages={289-97}
}
Scorpion toxins have long been used as tools in the investigation of neurotransmitter release mechanisms. We have used rat cortical synaptosomes to study the effects of a beta-type scorpion toxin (TiTX-gamma) on the release of glutamate and on the concentrations of free sodium and calcium ions inside the synaptosomes. The effects are compared with those of an alpha-type scorpion toxin (TsTX), on which there have been more studies. TsTX increased overall internal sodium and calcium ion… CONTINUE READING

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