Alpha-aminoadipyl-cysteinyl-valine synthetases in beta-lactam producing organisms. From Abraham's discoveries to novel concepts of non-ribosomal peptide synthesis.

@article{Martin2000AlphaaminoadipylcysteinylvalineSI,
  title={Alpha-aminoadipyl-cysteinyl-valine synthetases in beta-lactam producing organisms. From Abraham's discoveries to novel concepts of non-ribosomal peptide synthesis.},
  author={Juan F. Martin},
  journal={The Journal of antibiotics},
  year={2000},
  volume={53 10},
  pages={1008-21}
}
The tripeptide delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV) was discovered by ARNSTEIN and MORRIS in Penicillium chrysogenum and ABRAHAM and coworkers in Acremonium chrysogenum. Other analogous tripeptides and tetrapeptides were later reported in these and other beta-lactam producing fungi and actinomycetes. The ACV tripeptide is synthesized by a large non-ribosomal peptide synthetase named ACV synthetase encoded by the 11 kb pchAB gene. This gene has been cloned from the DNA of four… CONTINUE READING

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