Alpha-alkenoyl ketene S,S-acetal-based multicomponent reaction: an efficient approach for the selective construction of polyfunctionalized cyclohexanones.

Abstract

A versatile multicomponent reaction based on the new four-carbon synthons alpha-alkenoyl ketene S,S-acetals 1 has been developed. This three-component reaction of readily available alpha-alkenoyl ketene S,S-acetals 1 with aldehydes 2 and active methylene compounds 3 proceeds smoothly in acidic medium (glacial acetic acid in tetrahydrofuran) to give various… (More)
DOI: 10.1021/jo900217g

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