Alpha-adrenoreceptor-related dissociation constants and intrinsic efficacies of stereoisomers of epinephrine.

@article{Kim1981AlphaadrenoreceptorrelatedDC,
  title={Alpha-adrenoreceptor-related dissociation constants and intrinsic efficacies of stereoisomers of epinephrine.},
  author={Mi Young Kim and K N Salman and Popat N. Patil},
  journal={Blood vessels},
  year={1981},
  volume={18 4-5},
  pages={145-52}
}
THe alpha-adrenoreceptor-related dissociation constant and intrinsic efficacy of the stereoisomers of epinephrine were determined on the rabbit aortic strip. (-)-Epinephrine showed higher affinity than (+)-epinephrine or the desoxy analogue epinine. Efficacy of (+)-epinephrine relative to (-)-epinephrine was low (relative efficacy, er = 0.44). Epinephrine had about the same affinity and efficacy as (+)-epinephrine. When the alpha-adrenoreceptors were protected against dibenamine by an equimolar… CONTINUE READING

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