Alpha-adrenoceptors and alpha-adrenoceptor-mediated positive inotropic effects in failing human myocardium.

@article{Bhm1988AlphaadrenoceptorsAA,
  title={Alpha-adrenoceptors and alpha-adrenoceptor-mediated positive inotropic effects in failing human myocardium.},
  author={Michael B{\"o}hm and Frank Diet and Gisela Feiler and B. Kemkes and Erland Erdmann},
  journal={Journal of cardiovascular pharmacology},
  year={1988},
  volume={12 3},
  pages={357-64}
}
Experiments were designed to characterize cardiac alpha-adrenoceptors and the alpha-adrenoceptor-mediated positive inotropic effects in human myocardial tissue from patients with moderate New York Heart Association (NYHA) class II-III and severe (NYHA class IV) heart failure. The number of cardiac alpha-adrenoceptors was low but similar in moderate and severe heart failure (NYHA class II-III: 6.7 +/- 0.8 fmol/mg protein 3H-prazosin bound, n = 12; NYHA class IV: 7.4 +/- 0.9 fmol/mg protein 3H… CONTINUE READING