Alpha-actinin 4 and tumorigenesis of breast cancer.

  title={Alpha-actinin 4 and tumorigenesis of breast cancer.},
  author={Kuo-Sheng Hsu and Hung-Ying Kao},
  journal={Vitamins and hormones},
Alpha-actinins (ACTNs) were originally identified as cytoskeletal proteins which cross-link filamentous actin to establish cytoskeletal architect that protects cells from mechanical stress and controls cell movement. Notably, unlike other ACTNs, alpha-actinin 4 (ACTN4) displays unique characteristics in signaling transduction, nuclear translocation, and gene expression regulation. Initial reports indicated that ACTN4 is part of the breast cancer cell motile apparatus and is highly expressed in… CONTINUE READING
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