Alpha-actin isoform distribution in normal and failing human heart: a morphological, morphometric, and biochemical study.

@article{Suurmeijer2003AlphaactinID,
  title={Alpha-actin isoform distribution in normal and failing human heart: a morphological, morphometric, and biochemical study.},
  author={Albert J Suurmeijer and Sophie Cl{\'e}ment and Arianna Francesconi and Leonardo Bocchi and Annalisa Angelini and Dirk J. van Veldhuisen and Luigi Giusto Spagnoli and Giulio Gabbiani and Augusto Orlandi},
  journal={The Journal of pathology},
  year={2003},
  volume={199 3},
  pages={387-97}
}
We investigated the distribution of alpha-skeletal, alpha-cardiac, and alpha-smooth muscle actin isoforms in human heart during development, hypertrophy, and failure. At 20 weeks of fetal life, alpha-skeletal actin was localized in a small proportion of subendocardial and papillary muscle cardiomyocytes. At this gestation time, diffuse alpha-cardiac actin staining was observed, associated with focal expression of alpha-smooth muscle actin. In normal adult subjects, alpha-skeletal actin positive… CONTINUE READING