Corpus ID: 19171358

Alpha-Tocopherol and endothelial nitric oxide synthesis.

  title={Alpha-Tocopherol and endothelial nitric oxide synthesis.},
  author={R. Heller and G. Werner-Felmayer and E. Werner},
  journal={Annals of the New York Academy of Sciences},
Nitric oxide (NO), a central regulator of vascular tone and homeostasis, is generated upon activation of endothelial NO synthase (eNOS), which is mediated by an increase of intracellular calcium and/or by eNOS phosphorylation. A reduction of NO bioavailability leads to endothelial dysfunction that has been shown to be improved by alpha-tocopherol in certain conditions. The underlying mechanisms, however, are not completely clarified. The present study was performed to investigate whether alpha… Expand
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