Alpha-Tocopherol But Not Beta-Tocopherol Inhibits Thrombin-Induced PKC Activation and Endothelin Secretion in Endothelial Cells

@article{MartinNizard1998AlphaTocopherolBN,
  title={Alpha-Tocopherol But Not Beta-Tocopherol Inhibits Thrombin-Induced PKC Activation and Endothelin Secretion in Endothelial Cells},
  author={F. Martin-Nizard and A. Boullier and J. Fruchart and P. Duriez},
  journal={European Journal of Cardiovascular Prevention & Rehabilitation},
  year={1998},
  volume={5},
  pages={339 - 345}
}
  • F. Martin-Nizard, A. Boullier, +1 author P. Duriez
  • Published 1998
  • Medicine
  • European Journal of Cardiovascular Prevention & Rehabilitation
  • Introduction Production of endothelin by endothelial cells depends on protein-kinase C (PKC) stimulation which has been reported to be inhibited by alpha-tocopherol (α-Toch) but not by beta-tocopherol (β-Toch). The goal of this study was to determine whether α-Toch and β-Toch inhibit endothelin secretion by endothelial cells. Methods and results In a first set of experiments, cultured bovine aortic endothelial cells (BAEC) were incubated for 48 h with 100 μmol/l α-Toch or vehicle (0.1% ethanol… CONTINUE READING
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