Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis.

@article{Kim2009AlphaTcateninG,
  title={Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis.},
  author={Seung-Hyun Kim and B-Y Cho and Chitwan National Park and E-S Shin and Eunjin Cho and Evelyn Yang and Chan Wha Kim and Cong Seng Hong and Jeffrey E. Lee and Hyungbin Park},
  journal={Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology},
  year={2009},
  volume={39 2},
  pages={
          203-12
        }
}
BACKGROUND Toluene diisocyanate (TDI) is the most important cause of occupational asthma, but the genetic mechanism of TDI-induced asthma is still unknown. OBJECTIVE The objective of the study was to identify susceptibility alleles associated with the TDI-induced asthma phenotype. METHODS We conducted a genome-wide association study in 84 patients with TDI-induced asthma and 263 unexposed healthy normal controls using Affymetrix 500K SNPchip. We also investigated the relationships between… CONTINUE READING
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