Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain.

  title={Alpha-Synuclein Expression Restricts RNA Viral Infections in the Brain.},
  author={Erica L Beatman and Aaron Massey and Katherine D. Shives and Kristina S. Burrack and Mastooreh Chamanian and Thomas E Morrison and John David Beckham},
  journal={Journal of virology},
  volume={90 6},
UNLABELLED We have discovered that native, neuronal expression of alpha-synuclein (Asyn) inhibits viral infection, injury, and disease in the central nervous system (CNS). Enveloped RNA viruses, such as West Nile virus (WNV), invade the CNS and cause encephalitis, yet little is known about the innate neuron-specific inhibitors of viral infections in the CNS. Following WNV infection of primary neurons, we found that Asyn protein expression is increased. The infectious titer of WNV and Venezuelan… CONTINUE READING
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