Alpha-MSH reduces the internalization of Staphylococcus aureus and down-regulates HSP 70, integrins and cytokine expression in human keratinocyte cell lines.

@article{Donnarumma2004AlphaMSHRT,
  title={Alpha-MSH reduces the internalization of Staphylococcus aureus and down-regulates HSP 70, integrins and cytokine expression in human keratinocyte cell lines.},
  author={Giovanna Donnarumma and Iole Paoletti and Elisabetta Buommino and Maria Antonietta Tufano and Adone Baroni},
  journal={Experimental dermatology},
  year={2004},
  volume={13 12},
  pages={748-54}
}
Alpha-melanocyte-stimulating hormone (alpha-MSH) is a neuropeptide predominantly produced by the pituitary gland, but it is also generated by many extra-pituitary cells including keratinocytes of the skin. This neuropeptide has anti-inflammatory and antimicrobial effects and probably contributes in innate immunity. Staphylococcus aureus is the aetiological agent of a wide range of infections in humans. Colonization of human skin by S. aureus is a characteristic feature of several skin diseases… CONTINUE READING
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