Alpha-Lipoic Acid Prevents Endotoxic Shock and Multiple Organ Dysfunction Syndrome Induced by Endotoxemia in Rats

@article{Shen2015AlphaLipoicAP,
  title={Alpha-Lipoic Acid Prevents Endotoxic Shock and Multiple Organ Dysfunction Syndrome Induced by Endotoxemia in Rats},
  author={Hsin-Hsueh Shen and K. Lam and P. Cheng and Ching-Wen Kung and Shu-Ying Chen and Peisen Lin and Ming-Ting Chung and Y. Lee},
  journal={Shock},
  year={2015},
  volume={43},
  pages={405–411}
}
ABSTRACT Alpha-lipoic acid (ALA), a naturally occurring disulfide derivative of octanoic acid, serves as a strong antioxidant and has been reported to possess anti-inflammatory effects. The aim of the present study is to investigate the preventive and therapeutic effects of ALA on multiple organ dysfunction syndrome (MODS) caused by endotoxemia in rats. Male Wistar rats were intravenously infused with lipopolysaccharide (LPS) (10 mg/kg) to induce endotoxemia. Alpha-lipoic acid 10, 20, or 40 mg… Expand
Protective Effects of Antioxidant Peptide SS-31 Against Multiple Organ Dysfunctions During Endotoxemia
...
1
2
...

References

SHOWING 1-10 OF 63 REFERENCES
Effect of alpha-lipoic acid on LPS-induced oxidative stress in the heart.
Effects of lipoic acid on spleen oxidative stress after LPS administration.
Prophylaxis with α-lipoic acid against lipopolysaccharide-induced brain injury in rats
Lipoic acid suppresses portal endotoxemia-induced steatohepatitis and pancreatic inflammation in rats.
Protective effect of baicalein against endotoxic shock in rats in vivo and in vitro.
Aminoguanidine attenuates the delayed circulatory failure and improves survival in rodent models of endotoxic shock
α-Lipoic acid attenuates LPS-induced cardiac dysfunction through a PI3K/Akt-dependent mechanism.
...
1
2
3
4
5
...