Alpha-Glucosidase Promotes Hemozoin Formation in a Blood-Sucking Bug: An Evolutionary History

@inproceedings{Mury2009AlphaGlucosidasePH,
  title={Alpha-Glucosidase Promotes Hemozoin Formation in a Blood-Sucking Bug: An Evolutionary History},
  author={Fl{\'a}via Borges Mury and Jos{\'e} Roberto da Silva and L{\'i}gia Souza Ferreira and Beatriz dos Santos Ferreira and Gonçalo Apolin{\'a}rio de Souza-Filho and Jayme Augusto de Souza-Neto and Paulo Eduardo Martins Ribolla and Carlos Peres Silva and Viviane Veiga do Nascimento and Olga Lima Tavares Machado and Mar{\'i}lia Amorim Berbert-Molina and Mar{\'i}lvia Dansa-Petretski},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Hematophagous insects digest large amounts of host hemoglobin and release heme inside their guts. In Rhodnius prolixus, hemoglobin-derived heme is detoxified by biomineralization, forming hemozoin (Hz). Recently, the involvement of the R. prolixus perimicrovillar membranes in Hz formation was demonstrated. METHODOLOGY/PRINCIPAL FINDINGS Hz formation activity of an alpha-glucosidase was investigated. Hz formation was inhibited by specific alpha-glucosidase inhibitors. Moreover, Hz… CONTINUE READING

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