Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis.

@article{Oble2008AlphaCTLA4MP,
  title={Alpha-CTLA-4 mAb-associated panenteritis: a histologic and immunohistochemical analysis.},
  author={Darryl A. Oble and Mari Mino-Kenudson and Jeffrey Goldsmith and Frank Stephen Hodi and Rania M. Seliem and Glenn Dranoff and Martin C. Mihm and R. P. Hasserjian and Gregory Yves Lauwers},
  journal={The American journal of surgical pathology},
  year={2008},
  volume={32 8},
  pages={
          1130-7
        }
}
Monoclonal antibodies (mAbs) against the cytotoxic T lymphocyte antigen-4 (CTLA-4) molecule are used as an adjuvant to experimental tumor immunization protocols in the treatment of malignant melanomas and ovarian cancers. Aside from noted early therapeutic successes, a spectrum of adverse effects, including severe gastroenteritis, has been reported. We report herein our observations of 5 patients who developed severe gastrointestinal toxicity affecting the gastric, small intestinal, and colonic… CONTINUE READING
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