Alpha-B-crystallin induces an immune-regulatory and antiviral microglial response in preactive multiple sclerosis lesions.

@article{Bsibsi2013AlphaBcrystallinIA,
  title={Alpha-B-crystallin induces an immune-regulatory and antiviral microglial response in preactive multiple sclerosis lesions.},
  author={Malika Bsibsi and Inge R Holtman and Wouter H. Gerritsen and Bart J. L. Eggen and Erik W Boddeke and Paul D. L. P. M. van der Valk and Johannes M. van Noort and Sandra Amor},
  journal={Journal of neuropathology and experimental neurology},
  year={2013},
  volume={72 10},
  pages={970-9}
}
Microglial nodules are frequently observed in the normal-appearing white matter of multiple sclerosis (MS) patients. Previously, we have shown that these clusters, which we call "preactive MS lesions," are closely associated with stressed oligodendrocytes and myelin sheaths that contain markedly elevated levels of the small stress protein alpha-B-crystallin (HspB5). Here, we show that microglia in these lesions express the recently identified receptors for HspB5, that is, CD14, Toll-like… CONTINUE READING