Alpha-Asarone Protects Endothelial Cells from Injury by Angiotensin II

  title={Alpha-Asarone Protects Endothelial Cells from Injury by Angiotensin II},
  author={Hai-xia Shi and Jiajun Yang and Tao H. Yang and Yong-Liang Xue and Jun Liu and Ya-juan Li and Dan-Dan Zhang and J W Xu and Ka Bian},
  booktitle={Evidence-based complementary and alternative medicine : eCAM},
α -Asarone is the major therapeutical constituent of Acorus tatarinowii Schott. In this study, the potential protective effects of α -asarone against endothelial cell injury induced by angiotensin II were investigated in vitro. The EA.hy926 cell line derived from human umbilical vein endothelial cells was pretreated with α -asarone (10, 50, 100 µmol/L) for 1 h, followed by coincubation with Ang II (0.1 µmol/L) for 24 h. Intracellular nitric oxide (NO) and reactive oxygen species (ROS) were… CONTINUE READING


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