Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.

@article{Schraufstatter2009Alpha7S,
  title={Alpha 7 subunit of nAChR regulates migration of human mesenchymal stem cells.},
  author={Ingrid U. Schraufstatter and Richard G. Discipio and Sophia K. Khaldoyanidi},
  journal={Journal of stem cells},
  year={2009},
  volume={4 4},
  pages={203-15}
}
The efficient migration of mesenchymal stem cells (MSCs) to diseased tissues is required for the fulfillment of their regenerative potential. Recruitment of circulating cells into the damaged tissues is regulated by a complex network, which includes the non-neural cholinergic system. We found that human MSCs (hMSCs) express nicotinic acetylcholine receptor subunits alpha 7, beta 2 and beta 4. The receptor agonist nicotine caused calcium (Ca(++)) influx into hMSCs suggesting that the calcium ion… CONTINUE READING
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