Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia

@article{Martin2003Alpha7NR,
  title={Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia},
  author={Laura F. Martin and William R. Kem and Robert Freedman},
  journal={Psychopharmacology},
  year={2003},
  volume={174},
  pages={54-64}
}
Rationale and objectiveAuditory sensory gating, a biological measurement of the ability to suppress the evoked response to the second of two auditory stimuli, is diminished in people with schizophrenia. Deficits in sensory gating are associated with attentional impairment, and may contribute to cognitive symptoms and perceptual disturbances. This inhibitory process, which involves the alpha7 nicotinic receptor mediated release of gamma-aminobutyric acid (GABA) by hippocampal interneurons… 
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