Alpha-7 Nicotinic Receptor Signaling Pathway Participates in the Neurogenesis Induced by ChAT-Positive Neurons in the Subventricular Zone

@article{Wang2017Alpha7NR,
  title={Alpha-7 Nicotinic Receptor Signaling Pathway Participates in the Neurogenesis Induced by ChAT-Positive Neurons in the Subventricular Zone},
  author={Jianping Wang and Zhengfang Lu and Xiaojie Fu and Di Zhang and Lie Yu and Nan Li and Yufeng Gao and Xianliang Liu and Chunmao Yin and Junji Ke and Liyuan Li and Mengmeng Zhai and Shiwen Wu and Jiahong Fan and Liang Lv and Junchao Liu and Xuemei Chen and Qingwu Yang and Jian Wang},
  journal={Translational Stroke Research},
  year={2017},
  volume={8},
  pages={484-493}
}
Choline acetyltransferase-positive (ChAT+) neurons within the subventricular zone (SVZ) have been shown to promote neurogenesis after stroke in mice by secreting acetylcholine (ACh); however, the mechanisms remain unclear. Receptors known to bind ACh include the nicotinic ACh receptors (nAChRs), which are present in the SVZ and have been shown to be important for cell proliferation, differentiation, and survival. In this study, we investigated the neurogenic role of the alpha-7 nAChR (α7 nAChR… CONTINUE READING
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