Alpha 2a-interferon-induced differentiation of human alveolar rhabdomyosarcoma cells: correlation with down-regulation of the insulin-like growth factor type I receptor.

Abstract

Rhabdomyosarcoma, a tumor of skeletal muscle origin, appears developmentally arrested at an early stage in the myogenic differentiation pathway. The proliferation of an alveolar rhabdomyosarcoma cell line Rh30 is dependent on the insulin-like growth factor (IGF) II/IGF-I receptor (IGF-IR) signaling pathway and is highly sensitive to recombinant human IFN… (More)

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@article{Thulasi1996Alpha2D, title={Alpha 2a-interferon-induced differentiation of human alveolar rhabdomyosarcoma cells: correlation with down-regulation of the insulin-like growth factor type I receptor.}, author={Ramya Thulasi and Pureza Dias and Peter John Houghton and Janet A. Houghton}, journal={Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research}, year={1996}, volume={7 4}, pages={531-41} }