Alpha-2 receptors mediate an endogenous noradrenergic suppression of kindling development.

  title={Alpha-2 receptors mediate an endogenous noradrenergic suppression of kindling development.},
  author={R L Gellman and J A Kallianos and James O. McNamara},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={241 3},
We sought to elucidate the receptor subtype through which endogenous norepinephrine suppresses epileptogenesis in the rat kindling model. To this end we examined the effects of systemically administered selective antagonists and an alpha-2 agonist on kindling development and on kindled seizures. The alpha-2 adrenergic antagonists idazoxan, yohimbine and rauwolscine (0.1-10.0 mg/kg i.p.) dose-dependently facilitated amygdala kindling development. Central administration of idazoxan (20 micrograms… CONTINUE READING


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