Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype

@article{Galeotti2004Alpha2AM,
  title={Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype},
  author={N. Galeotti and A. Bartolini and C. Ghelardini},
  journal={Behavioural Brain Research},
  year={2004},
  volume={153},
  pages={409-417}
}
The activation of alpha2-adrenoceptors has been reported to impair memory functions in both rats and humans. The alpha2-adrenoceptor subtype responsible for this detrimental effect is still unknown. The effect of the alpha2-agonists clonidine and guanabenz on memory processes, in dependence to the time of administration, was evaluated in the mouse passive avoidance test. Clonidine (0.02-0.2 mg kg(-1) i.p.) and guanabenz (0.1-0.3 mg kg(-1) i.p.) induced amnesia in a dose-dependent manner. From… Expand
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