Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats.

@article{Bockman1996Alpha2AS,
  title={Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats.},
  author={Charles S. Bockman and I Gonzalez-Cabrera and Peter W. Abel},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1996},
  volume={278 3},
  pages={1235-43}
}
The alpha-2 adrenoceptor subtype and its signal transduction pathway mediating vascular relaxation in rats were studied in vitro using rings of superior mesenteric arteries. Removal of endothelium or incubation with NG-nitro-L-arginine completely blocked relaxant responses to UK14,304, suggesting endothelium-derived nitric oxide mediates relaxation. The order of potency for full (F) or partial (P) agonists causing relaxation was guanabenz (P) > UK14,304 (F) > clonidine (P) > epinephrine (F… CONTINUE READING